You may not be aware of it, but you have a lot of say in how the advertisements are placed on your website including the placement, layout, color, and style. There are many places on a website to put Adsense Ads. Some prefer to place it on the top of the page and others like the bottom of the page. Along either side of the text for your website is convenient too. Since we read from left to right, the right side is more common as it will attract attention as the eyes move across the page.
According to Google Adsense, the most effective location is at the top of the page because the entire ad can be seen. Often parts of it are hidden when on the sides unless the mouse is used to scroll over the information. This can be distracting to the consumer and lose the effectiveness of the advertisement. They also recommend using different colors for the ads to differentiate it from your website materials, but to use colors that compliment each other.
The layout can be modified to make it different or the same as your website. Some advertisement hosts like everything to be in the same style and size to give a symmetrical look to the pages. Others like to have their information completely distinct from the advertisements. Both are effective so it is only a matter of personal preference as to how you want your website to appear. Colors including the background can be changed to make everything work together well. You might have to experience a little to come up with the right design you are happy with.